Patterns and Trajectories of Behavioral and Neuropsychiatric Symptoms in Frontotemporal Dementia and Primary Progressive Aphasia
Our findings demonstrate that behavioral and neuropsychiatric symptoms are prevalent in both bvFTD and PPA. Their severity depends on the disease duration, phenotypic group, and sex. This detailed understanding of symptomatology is crucial for optimizing patient care, diagnostic evaluations, and the design of clinical trials. Limitations comprise the lack of neuropathologic validation and the limited availability of MRI data.
Authors
- Rene Günther
- Matthis Synofzik
- Hannah Asperger
- Jennifer Linn
- Francisco J. Martinez-Murcia
- Gabor C. Petzold
- Lukas Beichert
- Annika Spottke
- Eike Jakob Spruth
- Klaus Scheffler
- Olivia Wagemann
- Stefan Hetzer
- Elisabeth Dinter
- Daniel Janowitz
- Anna Christina Stockbauer
- Ingo Kilimann
- David Mengel
- Alexander Maximilian Bernhardt
- Michael Ewers
- Oliver Peters
- Doreen Müller
- Anna Gamez
- Sonja Schönecker
- Friederike Schroeck
- Anja Schneider
- Inga Zerr
- Katharina Buerger
- Julia Kustermann
- Renat Yakupov
- Björn H. Schott
- Jannis Denecke
- Lena Marth
- Peter Dechent
- Josef Priller
- Falk Lüsebrink
- Jens Wiltfang
- Julian Hellmann-Regen
- Catharina Prix
- Mathias Bähr
- Robert Malinowski
- Elisabeth Wlasich
- Johannes Prudlo
- Stefan J. Teipel
- Juan-Manuel Górriz-Sáez
- Agnes Flöel
- Andreas Hermann
- Klaus Fliessbach
- Johannes Levin
- Louise Droste zu Senden
- Emrah Duzel
- Wenzel Glanz
Institutions
- University of Bonn (DE)
- University of Cambridge (GB)
- Universitätsmedizin Greifswald (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Stroke Association (GB)
- Humboldt-Universität zu Berlin (DE)
- Instituto Andaluz de Ciencias de la Tierra (ES)
- Bridge University (SS)
- Max Planck Institute for Biological Cybernetics (DE)
- Munich Cluster for Systems Neurology (DE)
- MRB Research Center for Magnetic Resonance Bavaria (DE)
- Institut des Sciences Cognitives Marc Jeannerod (FR)
- German Center for Lung Research (DE)
- University Hospital Magdeburg (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Resonance Research (United States) (US)
- Cognitive Research (United States) (US)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- University of Rostock (DE)
- University of Aveiro (PT)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Neurology
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1212/wnl.0000000000214510
- Citations
- 1
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 29.71
Funders
- Eli Lilly and Company
- Biogen
- Teva Pharmaceutical Industries
- European Commission
- Deutsche Forschungsgemeinschaft
- Eisai
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ludwig-Maximilians-Universität München
- Servier
- Bayer Vital
- European Regional Development Fund