Deciphering stromal cell interactions in osteosarcoma highlights CDKN2A and MMP14 as novel diagnostic and therapeutic biomarkers

This study identified CDKN2A and MMP14 as potential OS biomarkers and elucidated their role within the stromal cell network, suggesting resveratrol as a candidate therapeutic molecule targeting MMP14. The present discoveries provided new insights for understanding the progression mechanisms and developing precise diagnosis and treatment strategies for OS.

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Publication Details

Journal
European journal of medical research
Published
2026-01-27
DOI
https://doi.org/10.1186/s40001-026-03902-2
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
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article

Deciphering stromal cell interactions in osteosarcoma highlights CDKN2A and MMP14 as novel diagnostic and therapeutic biomarkers

Jinwen Ge, Zhenhua Luo, Yicheng Sun, Xiwen Peng et al.
European journal of medical research
Single-cell and spatial transcriptomics
article

Deciphering stromal cell interactions in osteosarcoma highlights CDKN2A and MMP14 as novel diagnostic and therapeutic biomarkers

Jinwen Ge, Zhenhua Luo, Yicheng Sun, Xiwen Peng, Haobo Jiang
article en

Abstract

This study identified CDKN2A and MMP14 as potential OS biomarkers and elucidated their role within the stromal cell network, suggesting resveratrol as a candidate therapeutic molecule targeting MMP14. The present discoveries provided new insights for understanding the progression mechanisms and developing precise diagnosis and treatment strategies for OS.

European journal of medical researchVol. 31(1)
Hunan University of Traditional Chinese Medicine (CN), First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Openalex Percentile: Top 77%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
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Deciphering stromal cell interactions in osteosarcoma highlights CDKN2A and MMP14 as novel diagnostic and therapeutic biomarkers — Jinwen Ge, Zhenhua Luo, et al. · European journal of medical research (2026) | TGRS Research Map | TGRS