Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Nonfatal GCS frequently induce immediate, severe, non-apneic respiratory dysfunction temporally associated with severe hypoxia and bradycardia. Our study suggests that postictal respiratory and cardiac function are tightly coupled and highlights the importance of including all the relevant pathologic variables in studies of SUDEP pathogenesis. ANN NEUROL 2026.

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Publication Details

Journal
Annals of Neurology
Published
2026-01-27
DOI
https://doi.org/10.1002/ana.78164
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Samden D. Lhatoo, Rup K. Sainju, Brian K. Gehlbach, Haley E. Pysick et al.
Annals of Neurology
Epilepsy research and treatment
article

Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Samden D. Lhatoo, Rup K. Sainju, Brian K. Gehlbach, Haley E. Pysick, George B. Richerson, Xiaojin Li, Eduardo Bravo, Roshni Nair, Deidre N. Dragon, Laura Vilella
article en

Abstract

Nonfatal GCS frequently induce immediate, severe, non-apneic respiratory dysfunction temporally associated with severe hypoxia and bradycardia. Our study suggests that postictal respiratory and cardiac function are tightly coupled and highlights the importance of including all the relevant pathologic variables in studies of SUDEP pathogenesis. ANN NEUROL 2026.

Annals of Neurology
University of Iowa (US), Hospital Del Mar (ES), Iowa City VA Health Care System (US), The University of Texas Health Science Center (US)
National Institutes of Health, National Heart, Lung, and Blood Institute
Good health and well-being
Openalex Percentile: Top 78%
Epilepsy research and treatment
DOIOpen Access PDFOpenAlex
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