FOXM1 influences DNA methylation to augment <i>TACC3</i> alternative splicing directed by KAT2A in hepatocellular carcinoma
We uncovered TACC3-KAT2A as an emerging regulatory axis caused by alternative splicing in HCC and propose FOXM1-driven TACC3 inhibition to synergistically disrupt mitotic fidelity and transcriptional regulation, potentially offering new therapeutic avenues for HCC with reduced toxicity to the normal liver.
Authors
- Li Na Zhao
- Jesper B. Andersen
Institutions
- University of Copenhagen (DK)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2026-01-27
- DOI
- https://doi.org/10.3350/cmh.2025.1370
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Incyte
- Novo Nordisk