Prognostic Significance of Lymphocyte Percentage and IL-6 Level in Patients Undergoing Radiotherapy for Advanced Lung Cancer

Objective: Although most patients with locally advanced lung cancer show a moderate response to chemoradiotherapy, the results are not satisfactory.In lung cancer, lymphocyte percentages and interleukin-6 (IL-6) cytokine levels have been reported to be significantly correlated with survival rates.In this study, we investigated the effects of lymphocyte percentages and IL-6 levels on overall survival and progression-free survival.Methods: One hundred forty-two patients diagnosed with lung cancer and treated with radiotherapy were included in the study.Patients were examined according to gender, age, clinical stage, Eastern Cooperative Oncology Group performance status, pathology and pre-radiotherapy lymphocyte percentages and IL-6 cytokine levels.The results were also analyzed according to radiotherapy dose, treatment sites and response rates.Results: When comparing patients with lymphocyte percentage >15% to those with lymphocyte percentage 15%, median overall survival was 18 months and 7 months, progression-free survival was 17 and 5 months, respectively, and median overall survival and progression-free survival were significantly higher in those with lymphocyte percentage >15% (p=0.007 and p=0.006).When comparing patients with IL-6 7 pg/mL to those with >7 pg/mL, median overall survival was 14 and 7 months, progression-free survival was 9 and 4 months, and median overall survival and Z Ama: lerlemi akcier kanseri hastalarnn ounda, kemoradyoterapiyle orta dzeyde bir cevap alnsa da sonular yz gldrc deildir.Akcier kanserinde, lenfosit yzdeleri ve interlkin-6 (IL-6) sitokin dzeylerinin yaam oranlar ile anlaml dzeyde korelasyon gsterdii bildirilmitir.Bu almada, lenfosit yzdeleri ve IL-6 dzeylerinin genel sakalm ve progresyonsuz sakalm zerine etkisini aratrdk.Yntemler: almaya akcier kanseri tans alm ve radyoterapi grm 142 hasta dahil edildi