Microbiota-dependent mechanism of Jianpiyifei II in treating experimental virus-induced acute exacerbation of chronic obstructive pulmonary disease

JPYF II alleviated pulmonary inflammation, enhanced lung function, and reduced damage to lung structure and viral replication in a virus-induced AECOPD mouse model. The mechanisms involved the improvement of gut microbiota composition. Furthermore, JPYF II suppressed immune responses and the formation of emphysema by inhibiting the JAK-STAT signaling pathway, with these effects being dependent on the gut microbiota.

Authors

Institutions

Publication Details

Journal
Phytomedicine
Published
2026-01-27
DOI
https://doi.org/10.1016/j.phymed.2026.157891
Primary Topic
Andrographolide Research and Applications
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Microbiota-dependent mechanism of Jianpiyifei II in treating experimental virus-induced acute exacerbation of chronic obstructive pulmonary disease

Huameng Li, Jingyu Quan, Long Fan, Xuhua Yu et al.
Phytomedicine
Andrographolide Research and Applications
article

Microbiota-dependent mechanism of Jianpiyifei II in treating experimental virus-induced acute exacerbation of chronic obstructive pulmonary disease

Huameng Li, Jingyu Quan, Long Fan, Xuhua Yu, Miaona Zhang, Lin Lin, Zhihang Liu, Ting Cao, Lei Wu, Ziyao Liang
article en

Abstract

JPYF II alleviated pulmonary inflammation, enhanced lung function, and reduced damage to lung structure and viral replication in a virus-induced AECOPD mouse model. The mechanisms involved the improvement of gut microbiota composition. Furthermore, JPYF II suppressed immune responses and the formation of emphysema by inhibiting the JAK-STAT signaling pathway, with these effects being dependent on the gut microbiota.

PhytomedicineVol. 153
Guangzhou University of Chinese Medicine (CN)
Good health and well-being
Openalex Percentile: Top 76%
Andrographolide Research and Applications
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Microbiota-dependent mechanism of Jianpiyifei II in treating experimental virus-induced acute exacerbation of chronic obstructive pulmonary disease — Huameng Li, Jingyu Quan, et al. · Phytomedicine (2026) | TGRS Research Map | TGRS