Pretreatment emotional distress and peripheral biomarkers predict immune checkpoint inhibitor response in people with advanced inoperable gastroesophageal cancer
This prospective study demonstrates that ED and elevated PIMs significantly impair ICI efficacy in advanced GEC. The synergistic interaction between ED and PIMs suggests underlying psycho-inflammatory mechanisms affecting treatment outcomes. These findings establish the clinical importance of integrating routine psychological assessment and PIMs monitoring in cancer patients receiving immunotherapy.
Authors
- Huaidong Cheng
- Senbang Yao (ORCID: https://orcid.org/0000-0003-4769-4970)
- Yingxue Jia
- Yu Wu (ORCID: https://orcid.org/0000-0003-0139-8105)
- Mengqian Liu
- Jiaying Chai
- Guodong Nie
- Runze Huang (ORCID: https://orcid.org/0000-0002-7747-4883)
- Lijun Liu (ORCID: https://orcid.org/0000-0003-2803-6956)
- Ao Li
- Xueting Ding
- Han Ge
- Ling Cheng
- Mingjun Zhang
Institutions
- Tongji University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Anhui Medical University (CN)
- University of California, Irvine (US)
- Third Affiliated Hospital of Southern Medical University (CN)
- Shanghai Pulmonary Hospital (CN)
- Huainan Normal University (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1038/s43856-025-01358-9
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Shenzhen Hospital, Southern Medical University