Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta <sub>2</sub> ‐Adrenergic Agonist
Beta<sub>2</sub>-adrenergic stimulation induces proteomic adaptations that partially mimic resistance training, particularly in ribosomal proteins. Shared regulation of S100A13 and unique regulation of MUSTN1 with resistance training suggest distinct and complementary roles in regulating muscle growth. These findings indicate that the beta<sub>2</sub>-adrenergic receptor is a potential target to counter muscle atrophic conditions, offering a pharmacological approach for individuals unable to engage in resistance training.
Authors
- Anders Krogh Lemminger (ORCID: https://orcid.org/0000-0002-7929-7147)
- Ben Stocks (ORCID: https://orcid.org/0000-0002-9281-0793)
- Søren Jessen (ORCID: https://orcid.org/0000-0002-7461-1264)
- Angela Di Baldassarre (ORCID: https://orcid.org/0000-0002-4473-4909)
- Roger Moreno‐Justicia (ORCID: https://orcid.org/0000-0002-8587-4772)
- Andrea Di Credico (ORCID: https://orcid.org/0000-0002-8388-9305)
- Lukas Moesgaard (ORCID: https://orcid.org/0000-0002-6501-322X)
- Atul S. Deshmukh (ORCID: https://orcid.org/0000-0002-2278-1843)
- Jens Bangsbo
- Morten Hostrup
Institutions
- University of Copenhagen (DK)
- Novo Nordisk Foundation (DK)
- University of Chieti-Pescara (IT)
- IT University of Copenhagen (DK)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-25
- DOI
- https://doi.org/10.1002/jcsm.70175
- Primary Topic
- Sports Performance and Training
- Type
- article
- Field-Weighted Citation Impact
- 0.00