Comparison of the relative biological effectiveness of neutron irradiation of different energies on melanoma cells
The MeV-range neutron beam induced slightly stronger biological effects than the keV-range beam, but the observed RBE difference was notably smaller than the ∼50% gap predicted by ICRP models. Instead, the experimental trend closely aligned with previous theoretical RBE estimations based on secondary particle contributions. These results underscore the need to reevaluate current radioprotection weighting factors and support the refinement of neutron-based therapeutic protocols.
Authors
- María Pedrosa-Rivera (ORCID: https://orcid.org/0000-0002-5560-0658)
- B. Fernández (ORCID: https://orcid.org/0009-0003-2967-2214)
- R. Méndez-Villafañe
- J. Praena
- Cristina Méndez-Malagón (ORCID: https://orcid.org/0009-0009-4913-031X)
- M. Macías
- María José Ruiz-Magaña (ORCID: https://orcid.org/0000-0002-0673-8220)
- I. Porras
- Marta Oteo (ORCID: https://orcid.org/0000-0002-2855-3403)
- Laura Fernández-Maza
- Francisco Sánchez-Doblado
- Carmen Ruiz-Ruiz
Institutions
- Andalusian Health Service (ES)
- Universidad de Granada (ES)
- Centro Nacional de Aceleradores (ES)
- Centre for Science and Environment (IN)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1080/09553002.2026.2618528
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00