Redefining Treatment Paradigms for Glioma in Adolescents and Young Adults: Population-Based Evidence for Molecular Classification
The treatment strategies for AYA gliomas should be determined by molecular classification rather than age-based stratification. Adult-type and pediatric-type gliomas exhibit distinct biological and driver profiles. AYA gliomas exhibit significant molecular-anatomical heterogeneity, with specific anatomical regions demonstrating enrichment of molecular signatures.
Authors
- Guozhong Yi (ORCID: https://orcid.org/0000-0001-5306-4663)
- Yilamujiang Ainiwan (ORCID: https://orcid.org/0009-0002-1323-8352)
- Zhi Ting Ye (ORCID: https://orcid.org/0000-0002-9224-6627)
- Jing Wang (ORCID: https://orcid.org/0000-0002-4611-2003)
- Xian Zhang (ORCID: https://orcid.org/0000-0001-5499-2234)
- Y. Waterlily Huang (ORCID: https://orcid.org/0000-0001-5838-7656)
- Zhuoyang Chen (ORCID: https://orcid.org/0000-0002-5823-7698)
- Fen Mei
- Tao Liu
- Guanglong Huang
- Xiaomin Hou
- Shanqiang Qu
- Qiuming Pan
- Xin Zhang
- Hongrui Li
- Kuilin Liao
- Haiyan Xu
- Junlu Liu
Institutions
- Nanfang Hospital (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2496
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00