Intestinal microenvironment dynamics and Sepsis-associated encephalopathy pathophysiology: insights from multi-omics profiling
This study provides the first evidence of a fecal miRNA-gut microbiota interaction network in SAE pathogenesis, highlighting miR-30e-3p and miR-223-5p as pivotal mediators and potential diagnostic/therapeutic targets.
Authors
- Shao Song Xi
- Wen Bo Xu
- Wei Hu
- Fu Li Gu
- Yue Chen Zhang
- Zhou Xing Zhang
Institutions
- Zhejiang Chinese Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Westlake University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fneur.2025.1724644
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00