Diffuse leptomeningeal enhancement with optic nerve involvement in a patient with intracranial hypertension as the inaugural symptom of neurosarcoidosis

A 43-year-old female patient having a known history of pulmonary sarcoidosis presented with a rapidly developing intracranial hypertension, followed by a state of drowsiness. Cerebral MRI revealed intense leptomeningeal contrast enhancement and thickening of the pituitary gland. The present report detailed the primary imaging abnormalities observed in the patient and highlighted the importance of considering a differential diagnosis within the context of the clinical picture The clinical approach supporting the inflammatory origin of the observed imaging abnormalities in this case is discussed. Furthermore, this case highlighted the rapid effect of cortiotherapy in improving the neurological dysfunctions associated with neurosarciodosis which can be life-threatening.

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Publication Details

Journal
Oxford Medical Case Reports
Published
2025-12-08
DOI
https://doi.org/10.1093/omcr/omaf284
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
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article

Diffuse leptomeningeal enhancement with optic nerve involvement in a patient with intracranial hypertension as the inaugural symptom of neurosarcoidosis

Rania Zouari, Zakaria Saied, S. Ben Sassi, A. Rachdi et al.
Oxford Medical Case Reports
Sarcoidosis and Beryllium Toxicity Research
article

Diffuse leptomeningeal enhancement with optic nerve involvement in a patient with intracranial hypertension as the inaugural symptom of neurosarcoidosis

Rania Zouari, Zakaria Saied, S. Ben Sassi, A. Rachdi, Dina Ben Mohamed, Nebli Fatma
article en

Abstract

A 43-year-old female patient having a known history of pulmonary sarcoidosis presented with a rapidly developing intracranial hypertension, followed by a state of drowsiness. Cerebral MRI revealed intense leptomeningeal contrast enhancement and thickening of the pituitary gland. The present report detailed the primary imaging abnormalities observed in the patient and highlighted the importance of considering a differential diagnosis within the context of the clinical picture The clinical approach supporting the inflammatory origin of the observed imaging abnormalities in this case is discussed. Furthermore, this case highlighted the rapid effect of cortiotherapy in improving the neurological dysfunctions associated with neurosarciodosis which can be life-threatening.

Oxford Medical Case ReportsVol. 2026(1)
Tunis University (TN), National Institute of Neurology Mongi-Ben Hamida (TN), Tunis El Manar University (TN)
Openalex Percentile: Top 29%
Sarcoidosis and Beryllium Toxicity Research
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