Structure-guided engineering of prototype foamy virus Env identifies key residues for heparan sulfate binding and enhances transduction efficiency
These findings define the structural determinants of HS recognition in PFV Env and demonstrate that residue-level, structure-guided engineering can enhance PFV transduction efficiency. This study provides experimentally validated insight into PFV Env-HS interactions and establishes a rational framework for further optimization of PFV-based gene delivery technologies.
Authors
- Soo‐Yeon Cho
- Hee-Seung Shin
- Young Min Son (ORCID: https://orcid.org/0000-0003-2978-8703)
- Kyoung-Dong Kim (ORCID: https://orcid.org/0000-0002-2349-4512)
- Yujin Kwon (ORCID: https://orcid.org/0000-0002-7106-973X)
- Eui Tae Kim (ORCID: https://orcid.org/0000-0002-1631-3197)
- Seong-Mook Jung
- Eun Sang Seo
- Doyoun Kim
Institutions
- Korea Research Institute of Chemical Technology (KR)
- Chung-Ang University (KR)
- Jeju National University (KR)
- Sungkyunkwan University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fbioe.2026.1716928
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chung-Ang University
- Korea Health Industry Development Institute