HRQoL in adolescents with idiopathic isolated GHD: rhGH (dis)continuation in mid-puberty
Discontinuing rhGH in adolescents with IIGHD who tested GH-sufficient at mid-puberty does not appear to negatively affect perceived QoL. Parental reports suggest greater well-being in the discontinuation group, possibly reflecting pre-existing satisfaction with height and health. These findings emphasize considering both physical and psychosocial factors in treatment decisions and incorporating patient and parent perspectives during puberty.
Authors
- Annemieke M. Boot (ORCID: https://orcid.org/0000-0002-2426-3222)
- Theo Sas (ORCID: https://orcid.org/0000-0002-8727-1385)
- Jan J.V. Busschbach (ORCID: https://orcid.org/0000-0002-8602-0381)
- Saartje Straetemans (ORCID: https://orcid.org/0000-0001-7857-3608)
- Boudewijn Bakker (ORCID: https://orcid.org/0000-0003-0229-1123)
- Edmond H.H.M. Rings (ORCID: https://orcid.org/0000-0001-8195-4356)
- Edgar GAH van Mil
- Vera van Tellingen
- Joeri Vliegenthart (ORCID: https://orcid.org/0000-0003-4326-8595)
- Daniëlle C M van der Kaay
- Wit Jm
- Hetty van der Kamp
- Paul G Voorhoeve
- Robbert N. H. Touwslager
- Josine C. van der Heyden
- _ _
- Martijn J.J. Finken
- Christiaan de Bruin
- D. A. Schott
- Petra A. van Setten
- A. S. Paul van Trotsenburg
- Erica L.T. van den Akker
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Sint Franciscus Gasthuis (NL)
- Emma Kinderziekenhuis (NL)
- Reinier de Graaf Hospital (NL)
- St. Antonius Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Amalia Kinderziekenhuis (NL)
- Beatrix Kinderziekenhuis (NL)
- Willem-Alexander Kinderziekenhuis (NL)
- Zuyderland Medisch Centrum (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Hersenstichting (NL)
- Wilhelmina Children's Hospital (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Endocrine Connections
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1530/ec-25-0843
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw