Phenotypic Severity of <i>SCN5A</i> -Related Bradycardia Is Independent of Dominant-Negative and Coupled Gating Effects
Our findings suggest that coupled gating may be physiologically important for normal Na<sub>v</sub>1.5 function, and its loss can exacerbate disease severity.
Authors
- Ayami Tano
- Takafumi Iguchi (ORCID: https://orcid.org/0000-0002-2067-223X)
- Yoshihisa Nakagawa (ORCID: https://orcid.org/0000-0002-9411-9314)
- Takeru Makiyama (ORCID: https://orcid.org/0000-0002-9471-5335)
- Hideyuki Jinzai
- Kohei Yamauchi
- Horie Minoru
- Koichi Kato (ORCID: https://orcid.org/0009-0004-9622-0645)
- Seiko Ohno
- Yuichi Baba
- Toru Kubo
Institutions
- Shiga University of Medical Science (JP)
- Kyoto University (JP)
- Kochi Medical School Hospital (JP)
- National Cerebral and Cardiovascular Center (JP)
- Kōchi University (JP)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1161/circep.125.014270
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00