Humanized anti-CD33 CAR-T cells and antibody-drug conjugates for targeted therapy in acute myeloid leukemia
The CAR-T cells and ADCs developed in this study, based on humanized antibodies, showed significant anti-tumor efficacy in the AML model. Clone3HM-MMAE, in particular, demonstrated excellent anti-tumor activity along with a strong safety profile. These results strongly support the further development of targeted therapeutic strategies for AML.
Authors
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Huibin Huang (ORCID: https://orcid.org/0000-0002-8758-7937)
- L. Chen
- Chunling Huang
- Honghong Duan
- Zitong Wang
Institutions
- Fujian Medical University (CN)
- Johns Hopkins University (US)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fmed.2026.1691417
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian Medical University