Unmasking Hirata: a mysterious case of Hypoglycemia triggered by immunologic storm

We report a rare case of Insulin Autoimmune Syndrome in a 35-year-old woman with prior autoimmune features who developed hypoglycemia after an allergic reaction. Diagnosis was confirmed by insulin autoantibodies. Immunosuppressive therapy yielded significant improvement. This case suggests a broader autoimmune process may underlie seemingly isolated IAS presentations.

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Publication Details

Journal
Oxford Medical Case Reports
Published
2025-12-08
DOI
https://doi.org/10.1093/omcr/omaf289
Primary Topic
Diabetes Management and Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Unmasking Hirata: a mysterious case of Hypoglycemia triggered by immunologic storm

Mousa Atary, Amal Mansor, Yasmin Dahabreh, Mohammed AbuBaha et al.
Oxford Medical Case Reports
Diabetes Management and Research
article

Unmasking Hirata: a mysterious case of Hypoglycemia triggered by immunologic storm

Mousa Atary, Amal Mansor, Yasmin Dahabreh, Mohammed AbuBaha, Bara Abubaha, Hatem Taha, Hossam Salameh, Omar Marouf, Heba Qubaja
article en

Abstract

We report a rare case of Insulin Autoimmune Syndrome in a 35-year-old woman with prior autoimmune features who developed hypoglycemia after an allergic reaction. Diagnosis was confirmed by insulin autoantibodies. Immunosuppressive therapy yielded significant improvement. This case suggests a broader autoimmune process may underlie seemingly isolated IAS presentations.

Oxford Medical Case ReportsVol. 2026(1)
An-Najah National University (PS), Palestinian Hydrology Group (PS), Birzeit University (PS)
Good health and well-being
Openalex Percentile: Top 27%
Diabetes Management and Research
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