Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID
β-carbolines and <i>B. caapi</i> extract attenuate LPS-induced cytokine production in SH-SY5Y cells, supporting their anti-inflammatory and neuroprotective potential. The extract and β-carbolines also modulate ACE2 and TMPRSS2 expressions, suggesting relevance to mechanisms associated with neuro-COVID.
Authors
- Rafael Lanaro (ORCID: https://orcid.org/0000-0003-1014-0974)
- Ariadiny Lima Caetano (ORCID: https://orcid.org/0000-0002-3619-6485)
- Alessandra Linardi (ORCID: https://orcid.org/0000-0001-7628-7448)
- R F Righetti
- Tiago Nicoliche
- Iolanda de Fátima Lopes Calvo Tibério (ORCID: https://orcid.org/0000-0002-5662-7895)
- Roberta Sessa Stilhano (ORCID: https://orcid.org/0000-0002-0653-5968)
- Luciana Bianco (ORCID: https://orcid.org/0000-0003-3951-0916)
- Carla Máximo Prado
- Nelson Francisco Corrêa-Neto
- Rodrigo Portes Ureshino
Institutions
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Department of Physiological Sciences (RU)
- Hospital Universitário da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fphar.2025.1703727
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico