An in vitro co-culture model with CAR-T cells, antigen-presenting cells, and tumor cells to evaluate CAR-T cell-induced cytokine release syndrome
Macrophages and iDCs play a critical role in the development of CAR-T therapy-induced CRS. The triple-cell co-culture system, comprising CAR-T cells, macrophages or iDCs, and tumor cells, provides a viable <i>in vitro</i> model for assessing CAR-T cell-induced CRS.
Authors
- Zhe Qu (ORCID: https://orcid.org/0009-0001-6323-9305)
- Bo Li (ORCID: https://orcid.org/0000-0002-7294-6888)
- Shuangxing Li
- Na Li (ORCID: https://orcid.org/0000-0002-7850-2671)
- Xingchao Geng
- Hua Jiang
- Yanwei Yang
- Yuke Ren
- Ruiqiu Zhang
- Zhi Lin
- Guitao Huo
- Zixuan Lai
Institutions
- China Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institutes for Food and Drug Control (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fcimb.2026.1721114
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes for Food and Drug Control