Dual Non-C1 Synthon Role of CO <sub>2</sub> in Controlled Electrochemical Defluorination
The dual role of carbon dioxide (CO<sub>2</sub>) as a non-C1 synthon in controlled electrochemical defluorination has been exploited to produce monofluorinated or difluorinated products. In defluorination, CO<sub>2</sub> may fulfill two functions. First, serving as an electron-electron transfer mediator, it expedites the initial one-electron reduction. Second, acting as an electrophilic reagent, it reacts with the radical anion, diminishing its reduction potential and consequently facilitating the second one-electron reduction.
Authors
- Jie Liu (ORCID: https://orcid.org/0000-0003-0240-1740)
- Yangkai Dong
- Zixuan Zhang (ORCID: https://orcid.org/0000-0002-6932-5941)
- B. H. Wang
- Zhiwei Zhang
- Wenhao Fan
- Yulei Zhao
- Enbo Liu
Institutions
- Qufu Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c00031
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00