Genomic Characterization of Oncocytic Carcinoma of the Thyroid Using a Large Multi‐Institutional Database
The genomic landscape of OCA is marked by frequent TERT promoter mutations and distinct mutational patterns associated with patient gender and tumor metastatic status. These findings highlight potential molecular subtypes, reveal pathways potentially driving metastasis (eg, involving MEN1/TSC2), and identify novel sex-specific alterations (MST1R, PRKDC), offering avenues for improved development of targeted therapeutic strategies for OCA.
Authors
- Amanda J. Bastien (ORCID: https://orcid.org/0000-0002-2002-5737)
- Vinay Veluvolu (ORCID: https://orcid.org/0000-0003-2773-9465)
- Aliasgher Khaku
- Roshan Dongre
- Gabriel Bitar
- Saif Alshaka
- Julia Kuzniar
- Vijay Patel
- Beau Hsia
Institutions
- Rutgers, The State University of New Jersey (US)
- Creighton University (US)
- Cedars-Sinai Medical Center (US)
- University of Illinois Urbana-Champaign (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- James A. Haley Veterans' Hospital (US)
- Rutgers New Jersey Medical School (US)
- Texas A&M University (US)
Publication Details
- Journal
- Otolaryngology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1002/ohn.70115
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00