Paralytic Ileus in a 45-Year-Old Female with Schizophrenia on Clozapine Therapy

A 45-year-old woman who comes with complains of recurrent paradoxical loose stools and abdominal distension for 3 days. She had type II diabetes, schizophrenia, and a history of left below-knee amputation. While there was no indication of a mechanical blockage, imaging tests revealed paralytic ileus. A potentially fatal gastrointestinal side effect that is frequently associated with anticholinergic drugs, such as clozapine, is paralytic ileus. Full recovery was achieved with conservative treatment and a reduction in the dosage of clozapine. This instance highlights how important it is to identify and treat drug-induced gastrointestinal dysmotility as soon as possible.