Successful management of the recurrent acute in-stent thrombosis despite optimal medical therapy: a case report and review of the literature

This case illustrates how recurrent in-stent thrombosis may occur despite adherence to current procedural and pharmacological standards. Mechanical causes, particularly those not visible on angiography, should be actively investigated using intravascular imaging in patients with unexplained or repeated stent thrombosis. Early identification and correction of these issues, combined with aggressive control of metabolic risk factors, are essential for preventing further events and improving clinical outcomes.

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Publication Details

Journal
Journal of Medical Case Reports
Published
2026-01-27
DOI
https://doi.org/10.1186/s13256-025-05793-z
Primary Topic
Coronary Interventions and Diagnostics
Type
article
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article

Successful management of the recurrent acute in-stent thrombosis despite optimal medical therapy: a case report and review of the literature

Tohid Akbari, Farhan Shahid, Pouya Ebrahimi, Sara Montazeri Namin et al.
Journal of Medical Case Reports
Coronary Interventions and Diagnostics
article

Successful management of the recurrent acute in-stent thrombosis despite optimal medical therapy: a case report and review of the literature

Tohid Akbari, Farhan Shahid, Pouya Ebrahimi, Sara Montazeri Namin, Anwar Hussain, Vahid Eslami, Pedram Ramezani
article en

Abstract

This case illustrates how recurrent in-stent thrombosis may occur despite adherence to current procedural and pharmacological standards. Mechanical causes, particularly those not visible on angiography, should be actively investigated using intravascular imaging in patients with unexplained or repeated stent thrombosis. Early identification and correction of these issues, combined with aggressive control of metabolic risk factors, are essential for preventing further events and improving clinical outcomes.

Journal of Medical Case ReportsVol. 20(1)
Iran University of Medical Sciences (IR), Aston University (GB), NIHR Surgical Reconstruction and Microbiology Research Centre (GB), Shaheed Rajaei Cardiovascular Medical and Research Center (IR), Shahid Beheshti University of Medical Sciences (IR), Tehran University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 77%
Coronary Interventions and Diagnostics
DOIOpen Access PDFOpenAlex
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Successful management of the recurrent acute in-stent thrombosis despite optimal medical therapy: a case report and review of the literature — Tohid Akbari, Farhan Shahid, et al. · Journal of Medical Case Reports (2026) | TGRS Research Map | TGRS