Processing-induced changes in neuroprotective components and mechanisms of gardeniae fructus: integrating UPLC-Q-TOF-MS/MS, network pharmacology, and in vitro analysis
Geniposide and Crocetin were identified as key compounds responsible for the neuroprotective effects of GF and GFC, primarily through the inhibition of neuroinflammation and ferroptosis. Crocetin is highlighted as a potential marker for GFC.
Authors
- Haibo Liu
- Pei‐Gen Xiao
- Jiali Huang
- Ziyu Hou
- Leyang Fan
- Pei Ma
- Wenjie Wang
- Lijia Xu
- Le Sun
- Peiling Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Bioresources and Bioprocessing
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1186/s40643-025-01005-0
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences