Immunological profile of the tumor immune microenvironment of upper tract urothelial carcinoma predicts recurrence patterns
Our study demonstrated that CD4<sup>+</sup> T cells and Tregs in the TiME of patients with UTUC were independent predictors of high-risk recurrence together with high pathological stage. The analysis of TiME in surgical specimens may provide an objective indicator of the efficacy of adjuvant therapy in UTUC.
Authors
- Daichi Tamura (ORCID: https://orcid.org/0000-0001-9498-9996)
- Shigehisa Kitano (ORCID: https://orcid.org/0000-0002-4041-8298)
- Shigekatsu Maekawa (ORCID: https://orcid.org/0000-0003-4620-2831)
- Renpei Kato (ORCID: https://orcid.org/0000-0001-6089-7620)
- Ei Shiomi (ORCID: https://orcid.org/0000-0002-7221-4628)
- Ayato Ito (ORCID: https://orcid.org/0000-0002-6573-3999)
- 柳川 直樹
- Kenta Takahashi
- Mitsugu Kanehira
- Masakazu Abe
- Daiki Ikarashi
- Wataru Obara
Institutions
- Iwate Medical University (JP)
- Chemotherapy Foundation (US)
- Japan Society of Chemotherapy (JP)
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1007/s00262-025-04254-2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00