Meta-analysis of the association between HLA-G 14-bp insertion/deletion polymorphism and susceptibility to viral infections and cancer risk

This meta-analysis highlights the potential implication of virus structure, patient history, and ethnicity in HLA-G 14-bp I/D polymorphism regulation. This polymorphism appears to be associated withcancer susceptibility and immune protection during viral infection. It is hoped that further research will give more clinical utility of HLA-G polymorphism as a valuable molecular tool for prognostic assessment and therapy planning.

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Publication Details

Journal
Human Immunology
Published
2026-01-26
DOI
https://doi.org/10.1016/j.humimm.2026.111672
Primary Topic
Reproductive System and Pregnancy
Type
article
Field-Weighted Citation Impact
0.00
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article

Meta-analysis of the association between HLA-G 14-bp insertion/deletion polymorphism and susceptibility to viral infections and cancer risk

Hager Bourogâa, Issam Zidi, Abidur Rahman, Sabrine Dhouioui et al.
Human Immunology
Reproductive System and Pregnancy
article

Meta-analysis of the association between HLA-G 14-bp insertion/deletion polymorphism and susceptibility to viral infections and cancer risk

Hager Bourogâa, Issam Zidi, Abidur Rahman, Sabrine Dhouioui, N. Boujelbene, Amina Mokrani, Haifa Zaibi, Abdel Halim Harrath
article en

Abstract

This meta-analysis highlights the potential implication of virus structure, patient history, and ethnicity in HLA-G 14-bp I/D polymorphism regulation. This polymorphism appears to be associated withcancer susceptibility and immune protection during viral infection. It is hoped that further research will give more clinical utility of HLA-G polymorphism as a valuable molecular tool for prognostic assessment and therapy planning.

Human ImmunologyVol. 87(3)
Tunis University (TN), Wayne State University (US), King Saud University (SA), The Barbara Ann Karmanos Cancer Institute (US), Institut Salah-Azaïz (TN), Hôpital Charles-Nicolle (TN), Tunis El Manar University (TN)
Good health and well-being
Openalex Percentile: Top 77%
Reproductive System and Pregnancy
DOIOpen Access PDFOpenAlex
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Meta-analysis of the association between HLA-G 14-bp insertion/deletion polymorphism and susceptibility to viral infections and cancer risk — Hager Bourogâa, Issam Zidi, et al. · Human Immunology (2026) | TGRS Research Map | TGRS