Gut–brain axis biomarkers link intestinal inflammation to post-traumatic stress disorder vulnerability
We identified shared molecular pathways and core genes linking UC and PTSD. The comorbid model demonstrated that UC intensifies PTSD-like behaviors. Furthermore, Knockdown of Glrx in the PL alleviated fear retrieval following UC induction, establishing Glrx as a mechanistic node along the gut-brain axis in UC-associated PTSD vulnerability.
Authors
- X. Wang
- Rong Liu (ORCID: https://orcid.org/0000-0002-0575-3293)
- Jiazhi Jiang
- Junhui Liu (ORCID: https://orcid.org/0000-0002-3929-3723)
- Fei Zeng
- Gaomeng Luo
- Peng Huang
- Sha Liu
- Wei Wei
- Xiang Li
- Ziyue Xu
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1016/j.jad.2026.121284
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00