Antischistosomal activity of imidazolidine-2,4-dione derivatives

Schistosomiasis is a neglected tropical disease with limited treatment options and growing concerns over praziquantel resistance. We evaluated a series of 12 synthetic compounds for antiparasitic activity against <i>Schistosoma mansoni</i> adult worms <i>in vitro</i>. Isoindole-1,3-dione derivatives were inactive, whereas four imidazolidine-2,4-dione derivatives displayed selective antischistosomal activity with low cytotoxicity in mammalian cells. These findings highlight imidazolidine-2,4-dione as a promising scaffold for the development of new therapeutic agents against schistosomiasis.