Dexmedetomidine alleviates sepsis-associated acute kidney injury by inhibiting renal tubular ferroptosis via JNK/MAPK–LCN2 pathway
Dex mitigates ferroptosis in SA-AKI by counteracting sepsis-induced dysregulation of the JNK/MAPK-LCN2 axis. These findings provide novel mechanistic evidence supporting Dex as a potential therapeutic agent against SA-AKI.
Authors
- Shengxiang Ao
- Hongyan Xiao
- Tianyin Kuang
- Shuangqin Yin
- Jian Lü
- Fen Li (ORCID: https://orcid.org/0000-0002-8485-8965)
- Junyu Zhu
- Lin Qiao (ORCID: https://orcid.org/0000-0002-5840-1750)
- Li Luo
- Weihong Dai
- Jing Zhou
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Hainan Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1186/s40001-026-03953-5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00