An open, fully-processed data resource for studying mood and sleep variability in the developing brain
Brain development during adolescence and early adulthood coincides with shifts in emotion regulation and sleep. Despite this co-occurrence, very few existing datasets simultaneously characterize affective dynamics, sleep variation, and multimodal measures of brain development. Here, we describe the study protocol and initial release (n = 10) of an open data resource of densely sampled behavioral measures and neuroimaging in adolescents and young adults. Behavioral measures include ecological momentary assessment, actigraphy, extensive cognitive assessments, and detailed clinical phenotyping focused on emotion regulation. All participants also complete multi-echo functional MRI, compressed-sensing diffusion MRI, and advanced arterial spin-labeled MRI. All raw and processed data are openly available without a data use agreement and will be regularly updated as accrual continues. Together, this resource will accelerate research on the links between mood, sleep, and brain development.
Authors
- Juliette B. H. Brook
- RC Gur
- Mitchell Ja
- Elena C. Cooper
- Sheila Shanmugan (ORCID: https://orcid.org/0000-0001-7633-163X)
- Audrey C. Luo (ORCID: https://orcid.org/0000-0001-6798-1876)
- Joëlle Bagautdinova (ORCID: https://orcid.org/0000-0001-7201-467X)
- Damien A. Fair (ORCID: https://orcid.org/0000-0001-8602-393X)
- T. C. Moore
- Haochang Shou
- Kahini Mehta (ORCID: https://orcid.org/0000-0001-9466-100X)
- Philip Gehrman (ORCID: https://orcid.org/0000-0003-1054-7475)
- Timothy O. Laumann
- Erica B. Baller (ORCID: https://orcid.org/0000-0002-7987-3773)
- Manuel Taso (ORCID: https://orcid.org/0000-0003-2405-9165)
- Kathleen Merikangas
- Lauren White
- Matt Cieslak
- Brooke L. Sevchik
- Arno Klein
- Taylor Salo (ORCID: https://orcid.org/0000-0001-9813-3167)
- John A. Detre
- Aaron F. Alexander-Bloch
- Kosha Ruparel
- Theodore D. Satterthwaite
- Mark A. Elliott
- M. Dylan Tisdall
- Steven M. Nelson
- Michael P. Milham
- Phoebe Freedman
- Nina Laney
- Sage Rush
- Daniel H. Wolf
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Children's Hospital of Philadelphia (US)
- Washington University in St. Louis (US)
- University of Minnesota System (US)
- California University of Pennsylvania (US)
- Child Mind Institute (US)
- Siemens (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Aperture Neuro
- Published
- 2026-01-26
- DOI
- https://doi.org/10.52294/001c.151820
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Brain and Behavior Research Foundation
- University of Pennsylvania
- Perelman School of Medicine, University of Pennsylvania