Association of NK cells with a shift in tryptophan catabolism in patients with heart failure after a single exercise exertion
Collectively, our observations confirm earlier descriptive reports of exercise-induced upregulation of KYN production by NK cells and add mechanistic evidence that IL-12 induces a phenotype shift in NK cells, which is accompanied by accelerated TRP metabolism into KYN. Our data point to a concerted interaction between leukocyte subsets upon acute exercise, via the release of IL-12, with potential implications for differential energy metabolism and immune regulation in HFrEF.
Authors
- Kristin Lehnert (ORCID: https://orcid.org/0000-0003-2342-3949)
- Grażyna Domańska (ORCID: https://orcid.org/0000-0001-9710-6386)
- S Kaczmarek (ORCID: https://orcid.org/0000-0003-2215-6914)
- K Swaminathan
- Anke Hannemann (ORCID: https://orcid.org/0000-0002-2925-1124)
- Aycen Koc
- Ann‐Kristin Henning
- Nicolle Kränkel
- Bita Astan
- Martin Bahls
- C Templin
- Marcus Dörr
- Kathrin Budde
- Ulf Landmesser
Institutions
- Universitätsmedizin Greifswald (DE)
- Universität Greifswald (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1732461
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Bundesministerium für Bildung und Forschung
- Deutsche Stiftung für Herzforschung