Genomic and Clinical Impact of Smoking on Therapeutic Outcomes in Prostate Cancer: A Public Databases Analysis

Smoking history was significantly associated with aggressive clinicopathological features and a poor prognosis in patients with PCa. Our findings suggest that smokers with PCa may receive greater benefit from the early administration of taxane chemotherapy in comparison to other treatment regimens.

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Publication Details

Journal
The Prostate
Published
2026-01-26
DOI
https://doi.org/10.1002/pros.70134
Primary Topic
Prostate Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Genomic and Clinical Impact of Smoking on Therapeutic Outcomes in Prostate Cancer: A Public Databases Analysis

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The Prostate
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Genomic and Clinical Impact of Smoking on Therapeutic Outcomes in Prostate Cancer: A Public Databases Analysis

Keisuke Goto, Kenshiro Takemoto, Miki Naito, Yuki Kohada, Yoshinori Nakano, Keisuke Hieda, Kazuma Yukihiro, Nobuyuki Hinata, Shinsaku Tasaka, Naofumi Nomura, Go Kobayashi, Tomoya Hatayama, Akihiro Goriki, Hiroyuki Kitano, Yohei Sekino, Shunsuke Miyamoto, Kohei Kobatake
article en

Abstract

Smoking history was significantly associated with aggressive clinicopathological features and a poor prognosis in patients with PCa. Our findings suggest that smokers with PCa may receive greater benefit from the early administration of taxane chemotherapy in comparison to other treatment regimens.

The Prostate
Hiroshima University (JP), Radiation Effects Research Foundation (JP)
Good health and well-being
Openalex Percentile: Top 78%
Prostate Cancer Diagnosis and Treatment
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