Tocilizumab as a key therapeutic option in high-risk pediatric acute necrotizing encephalopathy
Key message Acute necrotizing encephalopathy (ANE) is a severe, in fectiontriggered encephalitis driven primarily by cyto kinemediated immune dysregulation rather than direct viral cytotoxicity. Tocilizumab, through targeted inhibition of interleu kin6 signaling, is an important therapeutic option for ANE that may improve survival and neurological out comes of highrisk pediatric patients.
Authors
- Jon Soo Kim (ORCID: https://orcid.org/0000-0003-2586-1942)
Institutions
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Clinical and Experimental Pediatrics
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3345/cep.2026.00073
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00