Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults

High preoperative plasma GFAP was associated with increased delirium incidence and severity, suggesting GFAP may serve as a risk marker for delirium. Brain vulnerability in the setting of astrocytosis may contribute to delirium pathophysiology.

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Publication Details

Journal
The Journals of Gerontology Series A
Published
2026-01-22
DOI
https://doi.org/10.1093/gerona/glag017
Primary Topic
Intensive Care Unit Cognitive Disorders
Type
article
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article

Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults

Hadia Fatima, S. R. Arnold, TAMARA G. FONG, Julianna Liu et al.
The Journals of Gerontology Series A
Intensive Care Unit Cognitive Disorders
article

Preoperative plasma glial fibrillary acidic protein and postoperative delirium in older adults

Hadia Fatima, S. R. Arnold, TAMARA G. FONG, Julianna Liu, A. Pascual-Leone, Richard Jones, Pia Kivisäkk, Mouhsin M Shafi, Long H Ngo, Michele Cavallari, Eva M Schmitt, Edward R Marcantonio, Sarinnapha M Vasunilashorn
article en

Abstract

High preoperative plasma GFAP was associated with increased delirium incidence and severity, suggesting GFAP may serve as a risk marker for delirium. Brain vulnerability in the setting of astrocytosis may contribute to delirium pathophysiology.

The Journals of Gerontology Series AVol. 81(4)
Brigham and Women's Hospital (US), Beth Israel Deaconess Medical Center (US), Harvard University (US), Brown University (US), Cancer Research And Biostatistics (US), MaineGeneral Medical Center (US), Hebrew SeniorLife (US), Berenson Allen Center for Noninvasive Brain Stimulation (US), University of Rochester (US)
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Openalex Percentile: Top 77%
Intensive Care Unit Cognitive Disorders
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