Synthetic biology for heparin biomanufacturing

Heparin, mainly used as an anticoagulant, has also shown potential in the treatment of diseases such as inflammation and cancer. Currently, heparin is mainly extracted from the intestinal mucosa of pigs. However, due to concerns about disease transmission and contamination associated with animal-derived products, biomanufacturing techniques have been explored as alternative production methods. Through enzyme engineering, metabolic engineering, and synthetic biology approaches, the heparin biosynthetic pathways have been systematically optimized. The main biomanufacturing techniques include in vivo/in vitro combination strategy (microbial heparosan fermentation followed by chemoenzymatic modification) and de novo biosynthesis. This article comprehensively discusses the latest advancements, challenges, and future perspectives of these heparin biomanufacturing techniques.

Authors

Institutions

Publication Details

Journal
Bioresources and Bioprocessing
Published
2026-01-27
DOI
https://doi.org/10.1186/s40643-025-00999-x
Citations
1
Primary Topic
Proteoglycans and glycosaminoglycans research
Type
article
Field-Weighted Citation Impact
23.07

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Synthetic biology for heparin biomanufacturing

Chang Zhou Dong, Jine Li, Lei Huang, Yingjia Pan et al.
1 citations
Bioresources and Bioprocessing
Proteoglycans and glycosaminoglycans research
23.07
article

Synthetic biology for heparin biomanufacturing

Chang Zhou Dong, Jine Li, Lei Huang, Yingjia Pan, Junyue Li, Jinshan Li, Z. Lewis Liu, Jiaying Wang, Xi Zhang, Lixue Yin, Jiazhang Lian, Zhinan Xu, Junzhong Li, Binying Lv, Jian Gao, Peng Wang
article en
1 citations

Abstract

Heparin, mainly used as an anticoagulant, has also shown potential in the treatment of diseases such as inflammation and cancer. Currently, heparin is mainly extracted from the intestinal mucosa of pigs. However, due to concerns about disease transmission and contamination associated with animal-derived products, biomanufacturing techniques have been explored as alternative production methods. Through enzyme engineering, metabolic engineering, and synthetic biology approaches, the heparin biosynthetic pathways have been systematically optimized. The main biomanufacturing techniques include in vivo/in vitro combination strategy (microbial heparosan fermentation followed by chemoenzymatic modification) and de novo biosynthesis. This article comprehensively discusses the latest advancements, challenges, and future perspectives of these heparin biomanufacturing techniques.

Bioresources and BioprocessingVol. 13(1)
Ministry of Education (NZ), Zhejiang University of Science and Technology (CN), Chinese Academy of Sciences (CN), Tianjin Institute of Industrial Biotechnology (CN), Institute of Mechanics (CN), University of Chinese Academy of Sciences (CN), Zhejiang University of Technology (CN), Zhejiang University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Openalex Percentile: Top 2%
Proteoglycans and glycosaminoglycans research
23.07
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Synthetic biology for heparin biomanufacturing — Chang Zhou Dong, Jine Li, et al. · Bioresources and Bioprocessing (2026) | TGRS Research Map | TGRS