Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis
This review systematically synthesised the evidence on quality of life measures and outcomes for people living with multiple long-term conditions in the Southeast Asia region. Results were analysed using a combination of methods, meta-analysis for studies where the same quality of life score was reported across three or more cohorts, and descriptive narrative synthesis. In total, 34 studies comprising 11,876 participants were included in the narrative synthesis and 14 of these were included in meta-analysis. The most common quality of life tools used included WHOQOL-BREF (n = 8) and EQ-5D-5L (n = 3) with pooled mean values of 70.47 (95% CI: 62.71 to 78.24) and 0.76 (95% CI: 0.67 to 0.84) respectively, indicating reduced but good quality of life. As healthcare systems adapt to the evolving challenges associated with multiple long-term conditions, understanding the tools and measures used to assess quality of life in different contexts becomes imperative to account for disease combinations and cultural nuances.
Authors
- Shavez Jeffers
- C Gillies
- Ashkon Ardavani (ORCID: https://orcid.org/0000-0002-9442-3295)
- Amrit Banstola (ORCID: https://orcid.org/0000-0003-3185-9638)
- Shabana Cassambai
- Natalia Oli
- Monika Arora (ORCID: https://orcid.org/0000-0001-9987-3933)
- A. Vaidya
- Shifalika Goenka
- Ruksar Abdala (ORCID: https://orcid.org/0009-0007-1164-2155)
- Nikhil Srinivasapura Venkateshmur
- Arron Peace
- AAKRUSHI BRAHMBHATT
- Sailesh Mohan
- Deborah Ikhile
- Dorairaj Prabhakaran
- Kamlesh Khunti
- Kuldeep Singh
- Mark P. Funnell
- Patrick Highton
- Prakash Mulakalapalli
Institutions
- University of Leicester (GB)
- All India Institute of Medical Sciences Jodhpur (IN)
- East Midlands Academic Health Science Network (GB)
- Centre for Chronic Disease Control (IN)
- Youth & Family Services (US)
- NIHR Research Delivery Network (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- Brunel University of London (GB)
- Middlesex University London (GB)
- Public Health Foundation of India (IN)
- Kathmandu Medical College Teaching Hospital (NP)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1038/s41467-025-68197-z
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of the United Kingdom
- National Institute for Health and Care Research
- British Heart Foundation
- NIHR Leicester Biomedical Research Centre