Case Report: Mixed ductal–lobular carcinoma consisting of invasive lobular carcinoma with a glycogen-rich clear cell pattern and elevated tumor mutation burden

In this case, the gILC and IDC components of an MDL shared a common origin, but exhibited marked genomic divergence. This experience also shows that SETD2 functional impairment may underlie gILC hypermutation, while HNF1B overexpression could contributes to a glycogen-rich clear cytoplasm. Overall, this case emphasizes the complexity of MDL with gILC, and highlights the need for further studies to clarify the underlying molecular mechanisms and their prognostic implications.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-26
DOI
https://doi.org/10.3389/fonc.2026.1741727
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
0.00

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article

Case Report: Mixed ductal–lobular carcinoma consisting of invasive lobular carcinoma with a glycogen-rich clear cell pattern and elevated tumor mutation burden

Tomoyuki Yokose, Kota Washimi, Rika Kasajima, Kae Kawachi et al.
Frontiers in Oncology
Breast Lesions and Carcinomas
article

Case Report: Mixed ductal–lobular carcinoma consisting of invasive lobular carcinoma with a glycogen-rich clear cell pattern and elevated tumor mutation burden

Tomoyuki Yokose, Kota Washimi, Rika Kasajima, Kae Kawachi, Yoichiro Okubo, Rui Yamaguchi, Yohei Miyagi, Yoichi Furukawa, Emi Yoshioka, Shinya Sato, Seiya Imoto
article en

Abstract

In this case, the gILC and IDC components of an MDL shared a common origin, but exhibited marked genomic divergence. This experience also shows that SETD2 functional impairment may underlie gILC hypermutation, while HNF1B overexpression could contributes to a glycogen-rich clear cytoplasm. Overall, this case emphasizes the complexity of MDL with gILC, and highlights the need for further studies to clarify the underlying molecular mechanisms and their prognostic implications.

Frontiers in OncologyVol. 16
Nihon University (JP), Jikei University School of Medicine (JP), Tokyo Medical University (JP), Kanagawa Prefectural Hospital Organization (JP), Aichi Cancer Center (JP), Odawara Municipal Hospital (JP), New York Genome Center (US), Institute for International Studies and Training (JP), Kanagawa Cancer Center, Nagoya University (JP)
Japan Society for the Promotion of Science, Institute of Medical Science, University of Tokyo
Openalex Percentile: Top 78%
Breast Lesions and Carcinomas
DOIOpen Access PDFOpenAlex
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Case Report: Mixed ductal–lobular carcinoma consisting of invasive lobular carcinoma with a glycogen-rich clear cell pattern and elevated tumor mutation burden — Tomoyuki Yokose, Kota Washimi, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS