Stroma-driven inter- and intratumoral heterogeneity of PD-L1 expression in cholangiocarcinoma: Implications for biomarker development and prognostic evaluation
Our data indicate that stroma content may be a surrogate for inflamed iCCA. Moreover, the inter- and intratumoral heterogeneity of iCCA poses a significant challenge to interpreting the PD-L1 signal. To establish tissue-based biomarkers in iCCA, a more granular annotation of their expression in different intratumoral compartments will be critical.
Authors
- Vadim Zhernovkov (ORCID: https://orcid.org/0000-0001-8903-1142)
- Anna Saborowski (ORCID: https://orcid.org/0000-0003-4857-4276)
- Nicole Krönke (ORCID: https://orcid.org/0000-0002-7087-784X)
- Jinbo Zhao (ORCID: https://orcid.org/0000-0002-2419-9566)
- Christoph Gerdes (ORCID: https://orcid.org/0000-0001-5351-5348)
- Jérémy Augustin (ORCID: https://orcid.org/0000-0001-8194-0624)
- Miguel Ibarra-Arellano
- Melanie Bathon
- Friedrich Feuerhake (ORCID: https://orcid.org/0000-0002-1234-982X)
- Julien Caldéraro (ORCID: https://orcid.org/0000-0002-5370-0807)
- Valery Volk (ORCID: https://orcid.org/0000-0002-8928-4470)
- Doan Duy Hai Tran (ORCID: https://orcid.org/0000-0003-2392-0259)
- Denis Schapiro (ORCID: https://orcid.org/0000-0002-9391-5722)
- Oreste Segatto (ORCID: https://orcid.org/0000-0003-2561-1142)
- Arndt Vogel
- Ilario Giovanni Rapposelli
- Anastasiia Korosteleva
- Steffen Lemke
- Walter Kolch
- Silke Marhenke
- Tanja Reineke-Plaaß
- Josephine Sophie Reschke
- Dawei Yi
- Simon Peters
Institutions
- University College Dublin (IE)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Heidelberg University (DE)
- Paris-Est Sup (FR)
- Toronto General Hospital (CA)
- University Hospital Heidelberg (DE)
- Princess Margaret Cancer Centre (CA)
- Medizinische Hochschule Hannover (DE)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Universitätsmedizin Göttingen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Hepatology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1097/hep.0000000000001686
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 39.15