Ursodeoxycholic acid alleviates high-fat diet-induced liver injury by modulating gut microbiota-mediated bile acid metabolism: an integrated microbiota-metabolomics analysis
These findings validate UDCA's multifaceted hepatoprotection <i>via</i> microbiota-bile acid crosstalk and metabolic-inflammatory modulation. The study provides a mechanistic basis for UDCA's traditional use in hepatobiliary disorders by integrating microbial, metabolic, and molecular evidence.
Authors
- Asmaa Ali (ORCID: https://orcid.org/0000-0002-7421-5085)
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-2793-0190)
- Yuchen Xie (ORCID: https://orcid.org/0000-0003-4838-7681)
- Hao Xu (ORCID: https://orcid.org/0000-0002-9036-8786)
- Xueyun Dong
- Keke Shao
- Xuehui Liu
- Min Chen
- Jiayuan He
- Wen Sun
- Leilei Zhang
- Liang Wu
Institutions
- Jiangsu University (CN)
- Ludovika University of Public Service (HU)
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Jiangsu Vocational College of Medicine (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Yancheng First People's Hospital (CN)
- Taiwan Centers for Disease Control (TW)
- ABB (Switzerland) (CH)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fnut.2026.1714100
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu University