Mitochondria-nucleus communication dictates progressive versus bimodal aging of the mammary gland
Non-linear aging, identified through oscillations in human plasma proteomics around 44 and 60, is postulated to contribute to the onset of diseases. Incidence of breast cancer follows such bimodal pattern. We show that mitochondria-nucleus matching in mice results in two mammary gland aging patterns, including a bimodal pattern associated with susceptibility to mammary tumor and that this bimodal signature is enriched in breast cancer patients diagnosed at 45 and 65.
Authors
- Thelma Mashaka
- Igor Bado (ORCID: https://orcid.org/0000-0001-8855-4750)
- Edmund C. Jenkins (ORCID: https://orcid.org/0000-0002-6448-090X)
- Mrittika Chattopadhyay
- Dmitry Polushakov
- Doris Germain
- Miguel Torres-Martin
- Daniela Sia
Institutions
- Tisch Hospital (US)
- Centre for Genomic Regulation (ES)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-25
- DOI
- https://doi.org/10.64898/2026.01.21.700824
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health