Risk of miscarriage after benzodiazepine use during pregnancy: updated systematic review and meta-analysis

This updated meta-analysis indicates that early pregnancy exposure to benzodiazepines is associated with an increased risk of miscarriage. The consistency across analyses and evidence of dose-response strengthen confidence in this association. Clinicians should carefully weigh risks and benefits, consider non-pharmacological alternatives, and ensure close monitoring when prescribing benzodiazepines to women of childbearing potential.