Sex-biased associations between gut microbiota and hematologic toxicity of neoadjuvant chemoradiotherapy in locally advanced rectal cancer
These results indicate that the differences in gut microbial composition and metabolism between the two sexes are associated with the sex-biased hematologic AEs induced by nCRT. Females require greater attention regarding the hematologic toxicity of chemoradiotherapy, and that gut microbes may serve as potential targets for sex-tailored strategies to restore hematopoietic function following chemoradiotherapy.
Authors
- X. Sui
- Huajing Teng (ORCID: https://orcid.org/0000-0001-9952-3618)
- Dezuo Dong (ORCID: https://orcid.org/0000-0001-6008-7193)
- Hongzhi Wang (ORCID: https://orcid.org/0000-0002-6499-6252)
- Bing Li (ORCID: https://orcid.org/0000-0002-2165-2636)
- Yong Cai
- Weihu Wang
- Yongheng Li (ORCID: https://orcid.org/0009-0007-7812-087X)
- Jianhao Geng
- Maxiaowei Song
- Shuai Li
- Chen Shi
- Wenyi Jiang
- Jun Xu
- Yangzi Zhang
- Xianggao Zhu
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1097/js9.0000000000004688
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00