Epithelial Reprogramming and Transition during Pulmonary Bioengineering
Recent research has emphasized the critical role of cell state transitions in tissue homeostasis. In lung biology, transitional cells are recognized as a feature of tissue-scale processes during both normal physiology and disease. The precise way that transitional cell states emerge and are regulated remains to be determined. Engineered tissues, built in a laboratory through bioengineering approaches, allow detailed study of cellular states that are not commonly found in native biology, and allow opportunities to directly induce and manipulate cellular transitions. The following study explores and characterizes epithelial cell states that emerge via cellular reprogramming in a tissue engineering context.
Authors
- Allison M. Greaney (ORCID: https://orcid.org/0000-0002-6316-0410)
- Micha Sam Brickman Raredon (ORCID: https://orcid.org/0000-0003-1441-6122)
- Maria Tomàs Gracia
- Themis R. Kyriakides (ORCID: https://orcid.org/0000-0002-1937-5764)
- Nuoya Wang
- David H. Stitelman (ORCID: https://orcid.org/0000-0001-8067-5830)
- Tomoshi Tsuchiya (ORCID: https://orcid.org/0000-0002-8419-1478)
- VI Lee
- Satoshi Mizoguchi (ORCID: https://orcid.org/0000-0002-6099-1702)
- Rachel Rivero
- Tomohiro Obata
- SF Ma
- Connor V Haynes (ORCID: https://orcid.org/0000-0001-6772-6365)
- Colten Danelski
- Sophie Elizabeth Edelstein
- Hahram Kim
Institutions
- Yale University (US)
- University of Toyama (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-26
- DOI
- https://doi.org/10.64898/2026.01.24.701406
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00