Infant Outcomes, Risk Factors, and Diagnostic Yield After a Brief Resolved Unexplained Event

This systematic review and meta-analysis found that infant mortality after a BRUE was exceedingly rare, and a serious underlying diagnosis was present in a small but important group of infants; most routine diagnostic tests added little value and not infrequently had false-positive results. Clinical focus should therefore shift from blanket investigations to a targeted, risk-informed approach grounded in a few reliable higher-risk features. These findings provide a robust evidence basis for guideline revision.

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Publication Details

Journal
JAMA Pediatrics
Published
2026-01-26
DOI
https://doi.org/10.1001/jamapediatrics.2025.5858
Citations
2
Primary Topic
Infant Health and Development
Type
article
Field-Weighted Citation Impact
136.78
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article

Infant Outcomes, Risk Factors, and Diagnostic Yield After a Brief Resolved Unexplained Event

David A. Gremse, Eric R. Coon, S Liebert, Mario Abaji et al.
2 citations
JAMA Pediatrics
Infant Health and Development
136.78
article

Infant Outcomes, Risk Factors, and Diagnostic Yield After a Brief Resolved Unexplained Event

David A. Gremse, Eric R. Coon, S Liebert, Mario Abaji, Alastair Fung, Peter J. Gill, Elise Peterson Lu, Joshua L. Bonkowsky, Amy M. DeLaroche, Joel S. Tieder, Nassr Nama, Bruce E. Herman, Kristy Carlin, Teresa Jewell, David D’Arienzo, Maida Chen, Eyal Sagiv
article en
2 citations

Abstract

This systematic review and meta-analysis found that infant mortality after a BRUE was exceedingly rare, and a serious underlying diagnosis was present in a small but important group of infants; most routine diagnostic tests added little value and not infrequently had false-positive results. Clinical focus should therefore shift from blanket investigations to a targeted, risk-informed approach grounded in a few reliable higher-risk features. These findings provide a robust evidence basis for guideline revision.

JAMA PediatricsVol. 180(3)
Western University (CA), University of Toronto (CA), University of Washington (US), Aix-Marseille Université (FR), University of Utah (US), Montreal Children's Hospital (CA), Hospital for Sick Children (CA), Assistance Publique Hôpitaux de Marseille (FR), Cancer Research And Biostatistics (US), Seattle Children's Hospital (US), Children's Hospital of Michigan (US), Seattle Public Library (US), SickKids Foundation (CA), McGill University (CA), University of South Alabama (US)
Good health and well-being
Openalex Percentile: Top 0%
Infant Health and Development
136.78
DOIOpen Access PDFOpenAlex
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