Hemoglobin A1c levels in patients with type 2 diabetes mellitus receiving oral semaglutide with versus without proton pump inhibitors: An exploratory study

HbA1c reduction at 52 weeks was significantly greater in the PPI co-administration group than in the group without PPI. Future research should include larger sample sizes and pharmacokinetic studies to clarify the clinical implications and interactions between oral semaglutide and PPIs.

Authors

Publication Details

Journal
International Journal of Clinical Pharmacology and Therapeutics
Published
2026-01-26
DOI
https://doi.org/10.5414/cp204899
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Hemoglobin A1c levels in patients with type 2 diabetes mellitus receiving oral semaglutide with versus without proton pump inhibitors: An exploratory study

Satoru Matsunuma, Yusuke Hirota, Koichi Yoshimoto
International Journal of Clinical Pharmacology and Therapeutics
Diabetes Treatment and Management
article

Hemoglobin A1c levels in patients with type 2 diabetes mellitus receiving oral semaglutide with versus without proton pump inhibitors: An exploratory study

Satoru Matsunuma, Yusuke Hirota, Koichi Yoshimoto
article en

Abstract

HbA1c reduction at 52 weeks was significantly greater in the PPI co-administration group than in the group without PPI. Future research should include larger sample sizes and pharmacokinetic studies to clarify the clinical implications and interactions between oral semaglutide and PPIs.

International Journal of Clinical Pharmacology and Therapeutics
Good health and well-being
Openalex Percentile: Top 79%
Diabetes Treatment and Management
DOISourceOpenAlex
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Hemoglobin A1c levels in patients with type 2 diabetes mellitus receiving oral semaglutide with versus without proton pump inhibitors: An exploratory study — Satoru Matsunuma, Yusuke Hirota, et al. · International Journal of Clinical Pharmacology and Therapeutics (2026) | TGRS Research Map | TGRS