A comparative ex vivo evaluation of colonization resistance against multidrug-resistant Enterobacterales in fecal samples from various animal species and strategies to augment it
These findings demonstrate that host-associated microbiota differ substantially in their ability to resist MDR <i>Enterobacterales</i> and that probiotic-mediated inhibition is influenced by microbial and metabolic context. Within a One Health framework, our results highlight the potential of prophylactic probiotic strategies to reduce the spread of MDR pathogens, particularly in livestock settings.
Authors
- Katharina Schaufler (ORCID: https://orcid.org/0000-0002-2669-8799)
- Andreas Vernunft (ORCID: https://orcid.org/0000-0001-8147-319X)
- Meina Neumann‐Schaal (ORCID: https://orcid.org/0000-0002-1641-019X)
- Elias Eger (ORCID: https://orcid.org/0000-0002-5514-8083)
- Pavaret Sivapornnukul (ORCID: https://orcid.org/0000-0002-6714-3407)
- Timo Homeier‐Bachmann (ORCID: https://orcid.org/0000-0002-8135-3814)
- Michael Schwabe (ORCID: https://orcid.org/0009-0006-8098-9841)
- Baerbel Hammerschmidt
- Till Strowig
- Sebastian Guenther
- Marie Wende
- Lisa Osbelt
Institutions
- Friedrich-Loeffler-Institut (DE)
- Universitätsmedizin Greifswald (DE)
- Medizinische Hochschule Hannover (DE)
- Universität Greifswald (DE)
- German Center for Infection Research (DE)
- Research Institute for Farm Animal Biology (FBN) (DE)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures (DE)
- Technische Universität Braunschweig (DE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.3389/fmicb.2025.1695208
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00