Executive function mediates the effects of genetic liability to schizophrenia on behavior and functioning in a community sample of children and adolescents
PRS-SZ was associated with poorer EF, which in turn mediated its associations with increased general psychopathology (p-factor) and anxiety symptoms, and reduced school performance in this community youth sample. EF may represent a hub through which PRS-SZ contributes to negative behavioral and functional outcomes.
Authors
- Carolina Ziebold
- Síntia Belangero (ORCID: https://orcid.org/0000-0002-2419-4351)
- Laís Fonseca (ORCID: https://orcid.org/0000-0003-2686-2752)
- Anthony Grace
- Lucas Toshio Ito (ORCID: https://orcid.org/0000-0001-9713-8687)
- Rohde Luis Augusto
- F. G. F. L. R Gomes
- Ary Gadelha (ORCID: https://orcid.org/0000-0002-0993-8017)
- Marcos Leite Santoro
- Eurípedes C. Miguel
- Rodrigo A. Bressan
- Pedro M. Pan
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Universidade de São Paulo (BR)
- Centro Universitário das Faculdades Metropolitanas Unidas (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Schizophrenia Research
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1016/j.schres.2026.01.014
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00