Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Testosterone dysfunction whether from deficiency or high-dose AAS exposure negatively impacts OTM, increasing bone resorption and promoting inflammation, potentially leading to long-term consequences for bone health and periodontal support. AAS at replacement doses may also impact PDL and bone during OTM.

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Publication Details

Journal
Journal of Periodontology
Published
2026-01-26
DOI
https://doi.org/10.1002/jper.70068
Primary Topic
Hormonal and reproductive studies
Type
article
Field-Weighted Citation Impact
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article

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Mírian Aiko Nakane Matsumoto, F. S Romano, Gabriela Leite Pedroso, Maria Bernadete Sasso Stuani et al.
Journal of Periodontology
Hormonal and reproductive studies
article

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Mírian Aiko Nakane Matsumoto, F. S Romano, Gabriela Leite Pedroso, Maria Bernadete Sasso Stuani, Daniela Silva Barroso de Oliveira, Gustavo Lopes Puls, Bruno Boaventura Vieira, Caio Luiz Bitencourt Reis, Leticia Cassaro, Erika Calvano Küchler, Kelly Galisteu‐Luiz
article en

Abstract

Testosterone dysfunction whether from deficiency or high-dose AAS exposure negatively impacts OTM, increasing bone resorption and promoting inflammation, potentially leading to long-term consequences for bone health and periodontal support. AAS at replacement doses may also impact PDL and bone during OTM.

Journal of Periodontology
Universidade Federal do Rio de Janeiro (BR), Universidade de Ribeirão Preto (BR), Universidade de São Paulo (BR), Universidade Federal de Alfenas (BR), University Hospital Bonn (DE), Universidade Federal do Estado do Rio de Janeiro (BR)
Openalex Percentile: Top 79%
Hormonal and reproductive studies
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Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study — Mírian Aiko Nakane Matsumoto, F. S Romano, et al. · Journal of Periodontology (2026) | TGRS Research Map | TGRS