The next-generation polyene EL219 is efficacious in an experimental model of central nervous system coccidioidomycosis caused by <i>Coccidioides immitis</i>

We evaluated the <i>in vivo</i> activity of EL219 against central nervous system coccidioidomycosis. Mice were inoculated intracranially with arthroconidia of <i>Coccidioides immitis</i>, and treatment with EL219 (5, 10, or 20 mg/kg QD by intraperitoneal injection) or fluconazole (25 mg/kg orally BID) began 2 days later. Each dose of EL219 and fluconazole significantly improved survival. Brain fungal burden was also reduced compared to vehicle control. Further studies of EL219 against coccidioidomycosis are warranted.