Cellular iron flux measurement by micromagnetic resonance relaxometry as a critical quality attribute of mesenchymal stromal cells
Our findings identify iron homeostasis as a potential chondrogenic-associated critical quality attribute of MSCs. This rapid, nondestructive monitoring strategy offers a promising approach to improve manufacturing efficiency and consistency by providing real-time insight into cellular iron flux. In addition, the methodology here impacts broader iron biology by providing a time-resolved iron flux measurement that is not currently available.
Authors
- Liang Cui (ORCID: https://orcid.org/0000-0002-5546-5097)
- Meiqi Kang
- Jongyoon Han
- Z. Yang
- Mengli Chen (ORCID: https://orcid.org/0000-0001-7641-8161)
- Yanmeng Yang
Institutions
- National University of Singapore (SG)
- Singapore-MIT Alliance for Research and Technology (SG)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1093/stcltm/szaf080
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation